ORs with 95% CIs of developing endometrial cancer according to quartiles of levels of compound groups (nmol/g lipid)a
Group of compounds | Modelb | OR (95% CI) | P for trendc | ||||||
---|---|---|---|---|---|---|---|---|---|
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||||||
All PCBsd | Age-adjusted | 1.0 | 1.2 (0.6–2.3) | 1.4 (0.7–2.6) | 1.5 (0.8–2.8) | 0.23 | |||
Multivariate | 1.0 | 1.1 (0.6–2.2) | 1.1 (0.6–2.2) | 1.2 (0.6–2.2) | 0.72 | ||||
Estrogenic compounds, not including CB 153e | Age-adjusted | 1.0 | 1.4 (0.7–2.7) | 1.6 (0.8–3.2) | 1.7 (0.8–3.4) | 0.15 | |||
Multivariate | 1.0 | 1.2 (0.6–2.4) | 1.2 (0.6–2.4) | 1.2 (0.6–2.4) | 0.76 | ||||
Estrogenic compounds, including CB 153f | Age-adjusted | 1.0 | 1.3 (0.7–2.4) | 1.0 (0.5–2.0) | 1.2 (0.6–2.4) | 0.74 | |||
Multivariate | 1.0 | 1.1 (0.6–2.1) | 0.9 (0.4–1.7) | 1.1 (0.6–2.2) | 0.90 | ||||
Antiestrogenic compoundsg | Age-adjusted | 1.0 | 1.8 (0.9–3.4) | 1.7 (0.9–3.4) | 1.7 (0.8–3.3) | 0.22 | |||
Multivariate | 1.0 | 1.7 (0.9–3.3) | 1.4 (0.7–2.8) | 1.5 (0.7–3.0) | 0.48 | ||||
Compounds with no known hormonal effect, | Age-adjusted | 1.0 | 1.2 (0.6–2.3) | 1.6 (0.9–3.0) | 1.6 (0.9–3.1) | 0.08 | |||
including p,p′-DDEh | Multivariate | 1.0 | 1.2 (0.6–2.2) | 1.4 (0.7–2.7) | 1.3 (0.7–2.4) | 0.39 | |||
Compounds with no known hormonal effect, | Age-adjusted | 1.0 | 1.8 (1.0–3.4) | 1.4 (0.7–2.7) | 1.3 (0.6–2.5) | 0.83 | |||
excluding p,p′-DDEi | Multivariate | 1.0 | 1.9 (1.0–3.6) | 1.6 (0.8–3.2) | 1.5 (0.7–3.0) | 0.47 |
a Including women with levels below the quantification limit (half of the quantification limit was taken as an estimated value).
b Multivariate adjusted for age and BMI.
c Tests for trend were performed by assigning consecutive integers to levels of categorized variables.
d CB 28, CB 52, CB 101, CB 105, CB 118, CB 138, CB 153, CB 156, CB 167, and CB 180.
e o,p′-DDT; p,p′-DDT; p,p′-DDD;β -HCH; γ-HCH; trans-nonachlor; oxychlordane; CB 28; CB 52; and CB 101.
f o,p′-DDT; p,p′-DDT; p,p′-DDD;β -HCH; γ-HCH; trans-nonachlor; oxychlordane; CB 28; CB 52; CB 101; and CB 153.
g CB 105, CB 118, CB 156, and CB 167.
h α-HCH, CB 138, CB 180, HCB, and p,p′-DDE.
i α-HCH, CB 138, CB 180, and HCB.