Table 1

Characteristics of study population and summary of DNA adducts analysis

SmokersNonsmokers
No.2024
Sex (male/female) 7/13 6/18
Agea39 ± 1134 ± 8
Cigarettes/daya17 ± 8 0
Tar/day (mg)a345 ± 196 0
Smoking yra20 ± 10  0
Pack-yra18 ± 14 0
Sputum induction (success/failure)18/2 21/3 
Lipophilic DNA adducts in sputum (NP1 digestion method)a,b3.1 ± 1.4c0.6 ± 0.8
Lipophilic DNA adducts in sputum (butanol extraction method)a,b4.6 ± 3.7d1.0 ± 1.9
  • a Results expressed as mean ± SD.

  • b Adducts/108 nucleotides as determined by 32P-postlabeling.

  • c Statistically significant compared to nonsmokers; P = 0.0007.

  • d Statistically significant compared to nonsmokers; P = 0.02.