Table 3

Mean rectal mucosal PGE2 content (pg/mg protein) before and after ibuprofen treatment

Ibuprofen dose (mg/day)Averaged baseline (before and at the end of the run-in period)After 2 wk of treatmentAfter 4 wk of treatment
0 (placebo)394.7 ± 221.8257.4 ± 180.9178.2 ± 91.5
300237.9 ± 128.6100.2 ± 91.598.6 ± 41.4
600215.6 ± 123.8133.1 ± 123.9115.1 ± 160.8