Table 2

Mean plasma ibuprofen levels (μg/ml) before and after daily ibuprofen treatment

Ibuprofen dose (mg/day)Before the placebo run-in periodAt the end of the placebo run-in periodAfter 2 wk of ibuprofen treatmentAfter 4 wk of ibuprofen treatment
0 (placebo)0 ± 00 ± 00 ± 00 ± 0
3000 ± 00 ± 012.7 ± 4.513.3 ± 3.2
6000.17 ± 0.52a0.20 ± 0.60a21.1 ± 6.1b26.3 ± 8.0b
  • a Resulted from ibuprofen levels seen in one individual.

  • b Significantly different from subjects taking 300 mg/day ibuprofen; P < 0.05.