Table 2

Prevalence of AGT codon 143 and 160 polymorphic genotypes in lung cancer cases and matched controls

Codon 143 genotype prevalenceCodon 160 genotype prevalence
Ile/IleIle/ValGly/GlyGly/Arg
African Americans
Cases70 (86)a11 (14)80 (99)a1 (1)
Controls76 (94)5 (6)77 (96)3 (4)
OR (95% CI)b2.3 (0.73–8.3)NDc
Caucasians
Cases41 (77)12 (23)53 (100)0 (0)
Controls47 (85)8 (15)52 (98)1 (2)
OR (95% CI)b2.0 (0.78–5.7)ND
Combined
Cases111 (83)23 (17)133 (99)1 (1)
Controls123 (90)13 (10)129 (97)4 (3)
OR (95% CI)b2.1 (1.01–4.7)0.25 (0.013–1.7)
Crude ORd2.1 (χ2 = 3.98; P = 0.047)0.24 (χ2 = 1.83; P = 0.182)
  • a Numbers in parentheses denote percentages.

  • b OR and 95% CI were calculated by conditional logistic regression analysis as described in “Materials and Methods.” Race was not used as a variable for our regression model when examining African Americans and Caucasians separately.

  • c ND, not determined.

  • d OR, χ2, and P values were calculated using the Pearson’s χ2 test.