Table 3

Effect of Se-methylselenocysteine or triphenylselenonium chloride on BrdUrd labeling and expression of PCNA, cyclin D1, and p27/Kip 1 in IDP cells of the mammary gland of rats given MNU

Treatment% of positively stained IDP cellsa
BrdUrdPCNACyclin D1p27/Kip 1
None21.9 ± 1.745.3 ± 2.867.2 ± 5.535.6 ± 2.5
Se-methylselenocysteine18.8 ± 1.544.4 ± 3.560.3 ± 4.849.7 ± 3.1b
Triphenylselenonium chloride14.3 ± 1.1b31.2 ± 2.2b40.8 ± 3.4b33.8 ± 2.9
  • a Results are expressed as mean ± SE (n = 6 rats/group). A total of 12–15 slides were evaluated per group. The slides for each assay were selected from different IDP size classes as shown in Table 2<$REFLINK> .

  • b P < 0.05 compared with the control group.