Table 1

Effect of Se-methylselenocysteine or triphenylselenonium chloride on BrdUrd labeling and expression of PCNA, cyclin D1, and p27/Kip 1 in TEB and alveolar cells of the mammary gland of pubescent rats

Treatment% of positively stained TEB cellsa,b
BrdUrdPCNACyclin D1p27/Kip 1
None17.8 ± 1.241.7 ± 3.556.2 ± 4.244.6 ± 3.2
Se-methylselenocysteine18.6 ± 1.539.6 ± 3.055.3 ± 3.747.0 ± 4.1
Triphenylselenonium chloride16.9 ± 1.438.5 ± 2.851.6 ± 3.942.8 ± 3.3
% of positively stained alveolar cellsa,c
TreatmentBrdUrdPCNACyclin D1p27/Kip 1
None11.5 ± 0.832.4 ± 2.744.3 ± 3.341.5 ± 4.0
Se-methylselenocysteine10.6 ± 0.830.8 ± 2.543.1 ± 3.043.1 ± 3.2
Triphenylselenonium chloride9.8 ± 1.229.9 ± 3.642.8 ± 3.740.7 ± 3.6
  • a Results are expressed as mean ± SE (n = 6 rats/group).

  • b A total of six to eight structures were evaluated per rat. Each structure consisted of 100–200 cells.

  • c A total of six to eight slides were evaluated per rat. Each field consisted of 100–250 cells.