Table 8

Frequency of aberrant crypt foci in homozgous rapid and slow acetylator congenic hamsters and inbred rats administered 3,2-dimethyl-4-aminobiphenyla

Species (strain)NAT2 genotypePhenotypeAberrant crypt foci
Syrian hamster (Bio.82.73/H) NAT2*15/*15 Rapid9.38 ± 1.55
NAT2*16A/*16A Slow3.30 ± 0.73
P < 0.001
Syrian hamster (Bio 1.5/H) NAT2*15/*15 Rapid21.2 ± 5.5
NAT2*16A/*16A Slow7.20 ± 1.66
P < 0.05
Rat (F344 and WKY) NAT2*20/*20 Rapid4.11 ± 1.06
NAT2*21A/*21A Slow1.57 ± 0.48
P < 0.05