Table 7

Acetylator genotype-dependent N-acetyltransferase activity in colon cytosol of congenic Syrian hamstera

SubstrateNAT2 genotypePhenotypeN-Acetyltransferase activity (nmol/min/mg)
CytosolNAT1NAT2
2-Aminofluorene NAT2*15/*15 Rapid6.16 ± 1.511.39 ± 0.1924.8 ± 3.2
NAT2*15/*16A Intermediate2.69 ± 0.300.97 ± 0.1911.7 ± 1.6
NAT2*16A/*16A Slow0.53 ± 0.040.96 ± 0.260.74 ± 0.29
(P < 0.0001)(P < 0.0001)
3,2′-Dimethyl-4-aminobiphenyl NAT2*15/*15 Rapid0.97 ± 0.241.06 ± 0.412.98 ± 0.36
NAT2*15/*16A Intermediate0.59 ± 0.070.68 ± 0.181.31 ± 0.15
NAT2*16A/*16A Slow0.31 ± 0.041.00 ± 0.350.05 ± 0.16
(P < 0.005)(P < 0.0005)