Table 2

Human NAT2 allelesa

AlleleNucleotide change(s)Amino acid change(s)Referencesb
NAT2*4 NoneNone24, 38, 39, 45, 49, 63, 64
NAT2*5A T341C, C481TIle114→Thr38, 65, 66, 69
NAT2*5B T341C, C481T, A803GIle114→Thr, Lys268→Arg39, 66, 68
NAT2*5C T341C, A803GIle114→Thr, Lys268→Arg65, 66, 67, 69
NAT2*5D T341CIle114→Thr70–73
NAT2*5E T341C, G590AIle114→Thr, Arg197→Gln70
NAT2*5F T341C, C481T, C759T, A803GIle114→Thr, Lys268→Arg74
NAT2*6A C282T, G590AArg197→Gln24, 38, 39, 65, 66
NAT2*6B G590AArg197→Gln66, 71, 72
NAT2*6C C282T, G590A, A803GArg197→Gln, Lys268→Arg71, 72
NAT2*6D T111C, C282T, G590AArg197→Gln73
NAT2*7A G857AGly286→Glu38, 49, 66
NAT2*7B C282T, G857AGly286→Glu24, 65
NAT2*12A A803GLys268→Arg66, 76
NAT2*12B C282T, A803GLys268→Arg66, 72
NAT2*12C C481T, A803GLys268→Arg69, 71, 72
NAT2*13 C282TNone66, 67, 70, 75
NAT2*14A G191AArg64→Gln69, 77
NAT2*14B G191A, C282TArg64→Gln77, 78
NAT2*14C G191A, T341C, C481T, A803GArg64→Gln, Ile114→Thr, Lys268→Arg70–72
NAT2*14D G191A, C282T, G590AArg64→Gln, Arg197→Gln70, 72
NAT2*14E G191A, A803GArg64→Gln, Lys268→Arg70
NAT2*14F G191A, T341C, A803GArg64→Gln, Ile114→Thr, Lys268→Arg72
NAT2*14G G191A, C282T, A803GArg64→Gln, Lys268→Arg73
NAT2*17 A434CGln145→Pro79
NAT2*18 A845CLys282→Thr79
  • a Updated from Ref. 26 . NAT2 nomenclature accessible on the internet.3 The allelic frequencies vary markedly with ethnicity. For review, see Ref. 11 .

  • b Initial reports, as opposed to an exhaustive list.