Table 1

GSTP1-1 allele and genotype frequencies and prostate cancer

GSTP1-1 allele and genotype frequencies and ORa and 95% CI for prostate cancer by GSTP1-1 allele and genotype, Physicians’ Health Study.

Cases n (%)Controls n (%)
Allele frequencies
ile 824 (69.8)1084 (67.5)
val 356 (30.2)522 (32.5)
Total11801606
P2 test of independence)0.2
Genotype frequencies
ile/ile 290 (49.1)365 (45.4)
ile/val 244 (41.4)354 (44.1)
val/val 56 (9.5)84 (10.5)
Total590803
P2 test of independence)0.4
Prostate cancer cases
Total (OR) [CI]High grade/stageb (OR) [CI]Low grade/stageb (OR) [CI]
Genotype
ile/ile 290 (1.00 ref)131 (1.00 ref)157 (1.00 ref)
ile/val 244 (0.87)117 (0.93)122 (0.80)
[0.69–1.09][0.70–1.25][0.60–1.06]
val/val 56 (0.84)22 (0.74)32 (0.87)
[0.58–1.22][0.44–1.24][0.56–1.37]
P-trend0.20.30.2
val/val 300 (0.86)139 (0.90)154 (0.81)
+ ile/val[0.70–1.07][0.68–1.18][0.63–1.06]
  • a Estimated from a logistic regression model controlling for the matching factors smoking status (never, former, current) and age.

  • b Does not sum to total because of missing histological grade and stage at diagnosis for some cases.