ORs for lipid-adjusted total PCBs and breast cancer, stratified by BMI
Cases | Controls | ORa (95% CI) | ORb (95% CI) | |
---|---|---|---|---|
Lowest third of BMIc | ||||
African-Americans | ||||
Total PCBsd | ||||
<0.312 | 29 | 24 | Referent | Referent |
0.312 to <0.54 | 38 | 30 | 1.13 (0.54–2.40) | 1.22 (0.54–2.73) |
≥0.54 | 35 | 33 | 0.90 (0.38–2.11) | 0.82 (0.32–2.08) |
Whites | ||||
Total PCBs | ||||
<0.265 | 54 | 36 | Referent | Referent |
0.265 to <0.417 | 69 | 35 | 1.50 (0.82–2.74) | 1.28 (0.67–2.42) |
≥0.417 | 49 | 57 | 0.90 (0.47–1.71) | 0.72 (0.36–1.46) |
Middle third of BMI | ||||
African-Americans | ||||
Total PCBs | ||||
<0.312 | 24 | 29 | Referent | Referent |
0.312 to <0.54 | 32 | 31 | 1.31 (0.59–2.90) | 1.11 (0.48–2.60) |
≥0.54 | 44 | 27 | 1.65 (0.63–4.36) | 2.51 (0.85–7.45) |
Whites | ||||
Total PCBs | ||||
<0.265 | 53 | 38 | Referent | Referent |
0.265 to <0.417 | 50 | 47 | 0.83 (0.45–1.52) | 0.81 (0.41–1.62) |
≥0.417 | 56 | 44 | 0.95 (0.49–1.85) | 0.77 (0.36–1.65) |
Highest third of BMI | ||||
African-Americans | ||||
Total PCBs | ||||
<0.312 | 23 | 33 | Referent | Referent |
0.312 to <0.54 | 25 | 28 | 2.09 (0.87–5.05) | 2.20 (0.86–5.63) |
≥0.54 | 33 | 27 | 3.83 (1.42–10.34) | 4.92 (1.63–14.83) |
Whites | ||||
Total PCBs | ||||
<0.265 | 39 | 55 | Referent | Referent |
0.265 to <0.417 | 52 | 45 | 1.79 (0.99–3.25) | 1.85 (0.97–3.54) |
≥0.417 | 29 | 29 | 1.79 (0.85–3.79) | 1.82 (0.79–4.20) |
a Adjusted for age, age-squared.
b Adjusted for age, age-squared, menopausal status, parity/lactation, HRT use, and income.
c Cutpoints for BMI (kg/m2) are race specific: <28.16, 28.16 to <34.2, and≥ 34.2 in African-Americans; <23.50, 23.50 to <27.94, and ≥27.94 in whites.
d Total PCBs in μg/g lipid. Cutpoints for total PCBs are race specific, based upon controls.