Table 4

Characteristics of 49 patients with pancreatic carcinoma and univariate analysis of p53 immunohistochemical staining in pancreatic cancer patients, San Francisco Bay Area 1995–1998

Characteristicnp53 negative n = 24p53 positive n = 25P
Age at diagnosis (±SD)4965.6 (±10.8)63.7 (10.8)0.76a
Sex0.25b
Male2414 (58%)10 (40%)
Female2510 (42%)15 (60%)
Race0.11c
White4222 (92%)20 (80%)
African-American41 (4%)3 (12%)
Asian31 (4%)2 (8%)
Diabetesd0.46b
Yes85 (21%)3 (12%)
No4119 (79%)22 (88%)
Tumor stage0.01c
I118 (33%)3 (12%)0.88e
II103 (13%)7 (28%)
III207 (29%)13 (52%)
IV55 (21%)0 (0%)
Unknown31 (4%)2 (8%)
Glandular differentiation0.002e
Well2315 (63%)8 (32%)
Moderately138 (33%)5 (20%)
Poorly131 (4%)12 (48%)
Nuclear atypia0.0007e
Mild1310 (42%)3 (12%)
Moderate1711 (46%)6 (24%)
Severe193 (13%)16 (64%)
Mitotic indexf0.17e
Low2916 (67%)13 (52%)
Medium157 (29%)8 (32%)
High51 (4%)4 (16%)
Tumor grade0.004e
I1912 (50%)7 (28%)
II1310 (42%)3 (12%)
III172 (8%)15 (60%)
  • a Student’s t-test.

  • b Fisher’s exact test.

  • c χ2 test.

  • d Self-reported diabetes diagnosed> 1 year prior to pancreatic cancer diagnosis.

  • e χ2 test for trend.

  • f Mitotic figures per 10 high-power fields: low, 0–5; medium, 6–10; high, >10.