Table 2

Characteristics of 61 patients with pancreatic carcinoma and univariate analysis of K-ras codon 12 mutation in pancreatic cancer patients, San Francisco Bay Area 1995–1998

CharacteristicnK-ras negative n = 15K-ras positive n = 46P
Age at diagnosis (±SD)6164.6 (±9.8)63.9 (±11.3)0.84a
Sex0.77b
Female349 (60%)25 (54%)
Male276 (40%)21 (46%)
Race1.00c
African-American41 (7%)3 (7%)
Asian41 (7%)3 (7%)
White5313 (86%)40 (86%)
Diabetesd0.002b
Yes86 (40%)2 (4%)
Average yr prior (±SD)10.8 (±6.5)4 (±2.8)
Range (yr)4–212–4
Tumor stage0.08e
I136 (40%)7 (15%)
II143 (20%)11 (24%)
III254 (26%)21 (45%)
IV51 (7%)4 (9%)
Unknown41 (7%)3 (7%)
Glandular differentiation0.59e
Well286 (40%)22 (48%)
Moderately157 (47%)8 (17%)
Poorly182 (13%)16 (35%)
Nuclear atypia0.32e
Mild155 (33%)10 (22%)
Moderate205 (33%)15 (33%)
Severe265 (33%)21 (45%)
Mitotic indexf0.71e
Low369 (60%)27 (59%)
Medium185 (33%)13 (28%)
High71 (7%)6 (13%)
Tumor grade0.54e
I236 (40%)17 (37%)
II165 (33%)11 (24%)
III224 (27%)18 (39%)
  • a Student’s t-test.

  • b Fisher’s exact test.

  • c χ2 test.

  • d Self-reported diabetes more than 1 year prior to pancreatic cancer diagnosis.

  • e χ2 test for trend.

  • f Mitotic figures per 10 high-power fields: low, 0–5; medium, 6–10; high, >10.