Table 5

Adjusted ORs for lung adenocarcinoma by p53 genotype and pack-years

Nonsmokers with the p53 Arg/Arg genotype were used as the reference group to show the adjusted OR for lung adenocarcinoma for a given pack-year and within p53 (Arg/Arg, Arg/Pro + Pro/Pro) genotype stratas.

p53 genotype
Arg/ArgArg/Pro + Pro/Pro
TotalCases96148
Controls237273
OR (95% CI)a1 (Ref.)b1.34 (0.98–1.83)
OR (95% CI)c1 (Ref.)1.45 (1.02–2.06)
Stratum, based on pack-years
0–29Cases3044
Controls150189
ORd11.2
95% CIRef.0.7–2.2
30–56Cases3153
Controls6054
ORd1.73.6
95% CI0.9–3.41.9–6.8
>56Cases3550
Controls2529
ORd5.46.1
95% CI2.6–11.33.1–12.2
  • a Crude OR.

  • b Ref., within reference values.

  • c Adjusted for sex, age, education, smoking status, pack-years.

  • d Adjusted for sex, age, education, smoking status.

  • 0–29 includes nonsmoker and pack-year <29 smokers.