Table 4

Adjusted ORs for lung adenocarcinoma by p53 genotype and pack-years

Nonsmokers with the p53 Arg/Arg genotype were used as the reference group to show the adjusted OR of lung adenocarcinoma for a given pack-year and within p53 (Arg/Arg, Arg/Pro + Pro/Pro/Pro) genotype stratas.

p53 genotype
Arg/ArgArg/Pro + Pro/Pro
TotalCases96148
Controls237273
OR (95% CI)a1 (Ref.)b1.34 (0.98–1.83)
OR (95% CI)c1 (Ref.)1.45 (1.02–2.06)
Stratum, based on pack-years
0Cases512
Controls7283
ORd13.1
95% CIRef.0.8–11.5
1–29Cases2532
Controls78106
ORd7.37.2
95% CI2.1–25.82.1–24.9
30–56Cases3153
Controls6054
ORc10.921.8
95% CI3.1–38.86.2–76.2
>56Cases3550
Controls2529
ORd34.138.9
95% CI9.2–126.110.7–140.5
  • a Crude OR.

  • b Ref., within reference values.

  • c Adjusted for sex, age, education, smoking status, pack-years.

  • d Adjusted for sex, age, education, smoking status.