Table 3

RRs and 95% CIs for breast cancer risk stratified by ADH3 genotype and daily alcohol consumption prior to diagnosis among postmenopausal women

ADH3 genotypeAlcohol consumptionP, test for trenda
None≤10 g/day>10 g/day
Combined
Cases, n (%)b89 (28)146 (46)86 (27)
Controls, n (%)b150 (32)210 (44)114 (24)
Matched RRc1.0 (Ref)d1.2 (0.8–1.7)1.2 (0.8–1.8)0.62
Multivariate RRe1.0 (Ref)1.3 (0.9–1.9)1.3 (0.9–2.1)0.41
Fast
Cases, n (%)34 (11)45 (14)25 (8)
Controls, n (%)48 (10)73 (15)33 (7)
Matched RRc1.0 (Ref)1.0 (0.5–1.7)1.1 (0.5–2.2)0.81
Multivariate RRe1.0 (Ref)1.0 (0.5–1.9)1.2 (0.5–2.8)0.60
Intermediate
Cases, n (%)40 (13)84 (26)41 (13)
Controls, n (%)73 (15)102 (22)57 (12)
Matched RRc0.9 (0.5–1.7)1.3 (0.7–2.2)1.1 (0.6–2.0)0.98
Multivariate RRe0.7 (0.4–1.5)1.2 (0.6–2.2)0.9 (0.5–1.9)0.71
Slow
Cases, n (%)15 (5)17 (5)20 (6)
Controls, n (%)29 (6)35 (7)24 (5)
Matched RRc0.8 (0.4–1.9)0.7 (0.3–1.5)1.3 (0.6–2.7)0.50
Multivariate RRe0.6 (0.2–1.5)0.6 (0.3–1.4)1.3 (0.5–3.0)0.17
LRT,f P = 0.56
LRT,g P = 0.45
  • a Unconditional logistic regression controlling for the matching factors was utilized for determining trend within each genotype because of small sample size.

  • b Numbers of cases and controls do not total 328 and 481 because of missing data on alcohol intake.

  • c Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.

  • d Ref, within reference values.

  • e In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.

  • f Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors.

  • g Likelihood ratio test for the interaction between genotype and alcohol consumption adjusted for the matching factors and previously described risk factors.