Table 1

ADH3 genotype and breast cancer risk

ADH3 genotypeCases, n (%)Controls, n (%)RR (95% CI) Matcheda,bRR (95% CI) Multivariatec,d
All women
Fast153 (33)211 (34)1.0 (Ref)e1.0 (Ref)
Intermediate239 (51)300 (48)1.2 (0.9–1.5)1.1 (0.8–1.4)
Slow73 (16)110 (18)1.0 (0.7–1.5)0.9 (0.6–1.3)
Premenopausal
Fast30 (33)35 (36)1.0 (Ref)1.0 (Ref)
Intermediate47 (52)48 (50)1.2 (0.6–2.2)1.1 (0.5–2.5)
Slow14 (15)14 (14)1.1 (0.5–2.8)1.4 (0.5–4.0)
Postmenopausal
Fast106 (32)157 (33)1.0 (Ref)1.0 (Ref)
Intermediate168 (51)236 (49)1.1 (0.8–1.5)0.9 (0.6–1.3)
Slow54 (17)88 (18)1.0 (0.6–1.5)0.7 (0.5–1.2)
  • a Matched on year of birth, menopausal status, postmenopausal hormone use, fasting status, time and date of blood draw.

  • b Unconditional logistic regression controlling for the matching factors was utilized for premenopausal women because of small sample size.

  • c In addition to matching factors, controlled for parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, weight gain since age 18, age of menopause, and duration of postmenopausal hormone use.

  • d Unconditional logistic regression controlling for the matching factors, parity, age of first birth, age of menarche, body mass index, family history, alcohol consumption, benign breast disease, and weight gain since age 18 was utilized for premenopausal women because of small sample size.

  • e Ref, within reference values.