Table 4

Comparison of LOH and MA frequencies between post-HD and sporadic breast cancers

Molecular abnormalityPost-HD tumors (n = 19)Sporadic tumors (n = 20)P
LOH
3p22–243 /14 (21%)5 /12 (42%)0.40
3p215 /18 (28%)7 /17 (41%)0.49
3p14–216 /13 (46%)3 /13 (23%)0.41
3p14.2 (FHIT gene)9 /17 (53%)4 /18 (22%)0.086
Any 3p11 /19 (58%)11 /20 (55%)1.00
5q22(APC-MCC region)3 /14 (21%)3 /14 (21%)1.00
6q13–145 /11 (45%)0 /140.01
6q22–274 /15 (27%)2 /14 (14%)0.65
Any 6q8 /19 (42%)2 /20 (10%)0.03
8p8 /18 (44%)5 /20 (25%)0.31
9p214 /11 (37%)0 /150.02
11q6 /19 (32%)7 /20 (35%)1.00
13q (RB gene)6 /16 (38%)5 /19 (26%)0.72
17p (TP53 gene)16 /19 (84%)7 /15 (47%)0.03
17q (BRCA1 region)7 /16 (44%)5 /18 (28%)0.48
FAL index meana0.3820.2480.12
FRL index mean0.4290.2990.17
MA frequency5 /19 (26%)2 /20 (10%)0.24
MA index mean0.0210.0050.16
  • a FAL index is an indicator of LOH at all microsatellite markers (n = 20) analyzed by case (range, 0–1); FRL index is an indicator of LOH at all chromosomal regions examined (n = 13); MA index is an indicator of alterations at all microsatellite markers (n = 20) analyzed by case (range, 0–1).