Table 3

Comparison of LOH and MA frequencies between post-HD and sporadic lung cancers

Molecular abnormalityPost-HD tumors (n = 19)Sporadic tumors (n = 57)P
LOH
3p22–2412 /17 (71%)38 /56 (68%)1.00
3p2114 /19 (74%)39 /57 (68%)0.78
3p14–216 /10 (60%)24 /38 (63%)1.00
3p14.2 (FHIT gene)9 /15 (60%)38 /52 (73%)0.35
3p127 /15 (47%)31 /46 (64%)0.22
Any 3p15 /19 (79%)53 /57 (93%)0.10
5q22 (APC-MCC region)6 /14 (43%)16 /43 (37%)0.76
9p217 /18 (39%)29 /49 (59%)0.22
13q (RB gene)4 /13 (31%)16 /28 (57%)0.18
17p (TP53 gene)13 /14 (93%)31 /39 (80%)0.41
Mean FAL indexa0.5120.5710.37
Mean FRL index0.5920.6720.24
MA frequency14 /19 (74%)23 /57 (40%)0.017
Mean MA index0.0870.0360.004
  • a FAL index is an indicator of LOH at all microsatellite markers (n = 20) analyzed by case (range, 0–1); FRL index is an indicator of LOH at all chromosomal regions (n = 9) examined (range, 0–1); MA index is an indicator of LOH at all microsatellite markers (n = 20) analyzed by case (range, 0–1).