Table 2

TP53 mutations in post-HD lung and breast tumors

Tumor typeCase no.Exon/codonBase substitution/amino acid changeType of mutation
Lung2Exon 7/codon 2451-bp insertion (T)Frameshift
Lung3Exon 5/codon 135TGC to TGG/Cys to TrpC to G, transversion
Lung8Exon 5/codon 141TGC to TGG/Cys to TrpC to G, transversion
Lung10Exon 5/codon 179CAT to CGT/His to ArgA to G, transition
Lung12Exon 7/codon 248CGG to CTG/Arg to LeuG to T, transversion
Lung13Exon 5/codon 154GGC to GTC/Gly to ValG to T, transversion
Lung14Exon 5/codon 164AAG to AAC/Lys to AsnG to C, transversion
Lung15Exon 5/codon 135TGC to TGG/Cys to TrpC to G, transversion
Lung16Exon 8/codon 275TGT to TAT/Cys to TyrG to A, transition
Lung18Exon 7/codon 238TGT to TGG/Cys to TrpT to G, transversion
Lung19Exon 8/codon 283CGG to TGG/Arg to TrpC to T, transition
Breast8Exon 6/codon 213CGA to CAA/Arg to GlnG to A, transition
Breast10Exon 7/codon 248CGG to CAG/Arg to GlnG to A, transition