Table 1

Genotype and allele numbers and frequencies in subjects according to smoking history

Aomori subjects (n = 148)Tsuchiura subjects (n = 239)Total subjects (n = 387)
Lifetime nonsmokerEx-smokerNonsmokeraSmokerLifetime nonsmokerEx-smokerNonsmokeraSmokerLifetime nonsmokerEx-smokerNonsmokeraSmoker
Genotype (n)(40)(19)(59)(89)(42)(84)(126)(113)(82)(103)(185)(202)
L/L101423553369
S/L921127918273918203866
S/S30174758316394696180141127
 Presence of L allele (%)25%11%20%35%26%25%25%39%26%22%24%37%
Allele (n)(80)(38)(118)(178)(84)(168)(252)(226)(164)(206)(370)(404)
L11213351324374924265084
S693610514371144215177140180320320
L (%)14%5%11%20%15%14%15%22%15%13%14%21%
OR (95% CI)b, Pc
L/L+ L/S vs S/SOR = 2.1(1.0–4.3), P = 0.04OR = 1.9(1.1–3.2), P = 0.02OR = 1.9(1.2–2.9), P = 0.003
L vs SOR = 2.0(1.0–3.8), P = 0.03OR = 1.6(1.0–2.6), P = 0.03OR = 1.7(1.1–2.5), P = 0.005
  • a Nonsmokers are lifetime nonsmokers and ex-smokers.

  • b Nonsmoker versus smoker.

  • c Fisher’s exact test.