Table 4

Age-adjusted risk of colorectal cancer according to MTR genotype and alcohol intake among United States physicians and health professionals in the PHS and HPFS

MTR genotypeAlcohol intake
<1 drink/day≥1 drink/day
asp/asp
 Number162/21086/104
 OR (95% CI)1.00 (ref.)1.04 (0.73–1.49)
gly/asp
 Number57/8641/50
 OR (95% CI)0.88 (0.59–1.30)1.03 (0.64–1.63)
gly/gly
 Number4/196/3
 OR (95% CI)0.27 (0.09–0.81)2.64 (0.65–10.82)
Ptrend = 0.04Ptrend = 0.52
Pinteraction = 0.04