Table 3

Age-adjusted risk of colorectal cancer according to MTR and MTHFR genotypes and levels of folate and homocyst(e)ine among the PHS participants

Folate (ng/ml)Homocyst(e)ine (mg/dl)
Tertile 1Tertile 2 and 3Tertile 1 and 2Tertile 3
MTR asp/asp or gly/asp
 Number51/102128/203100/18664/93
 OR (95% CI)0.84 (0.56–1.27)1.00 (ref)1.00 (ref)1.21 (0.81–1.82)
MTR gly/gly
 Number3/43/104/72/4
 OR (95% CI)1.25 (0.27–5.69)0.51 (0.14–1.90)1.10 (0.31–3.90)1.05 (0.19–5.85)
Pinteraction = 0.22Pinteraction = 0.37
MTHFR ala/ala or val/ala
 Number45/83117/171100/16757/79
 OR (95% CI)0.88 (0.56–1.36)1.00 (ref)1.00 (ref)1.16 (0.76–1.78)
MTHFR val/val
 Number8/186/284/259/18
 OR (95% CI)0.57 (0.24–1.38)0.29 (0.12–0.73)0.25 (0.08–0.74)0.69 (0.29–1.62)
Pinteraction = 0.16Pinteraction = 0.24