Age-adjusted risk of colorectal cancer according to MTR and MTHFR genotypes and levels of folate and homocyst(e)ine among the PHS participants
| Folate (ng/ml) | Homocyst(e)ine (mg/dl) | |||||
|---|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 and 3 | Tertile 1 and 2 | Tertile 3 | |||
| MTR asp/asp or gly/asp | ||||||
| Number | 51/102 | 128/203 | 100/186 | 64/93 | ||
| OR (95% CI) | 0.84 (0.56–1.27) | 1.00 (ref) | 1.00 (ref) | 1.21 (0.81–1.82) | ||
| MTR gly/gly | ||||||
| Number | 3/4 | 3/10 | 4/7 | 2/4 | ||
| OR (95% CI) | 1.25 (0.27–5.69) | 0.51 (0.14–1.90) | 1.10 (0.31–3.90) | 1.05 (0.19–5.85) | ||
| Pinteraction = 0.22 | Pinteraction = 0.37 | |||||
| MTHFR ala/ala or val/ala | ||||||
| Number | 45/83 | 117/171 | 100/167 | 57/79 | ||
| OR (95% CI) | 0.88 (0.56–1.36) | 1.00 (ref) | 1.00 (ref) | 1.16 (0.76–1.78) | ||
| MTHFR val/val | ||||||
| Number | 8/18 | 6/28 | 4/25 | 9/18 | ||
| OR (95% CI) | 0.57 (0.24–1.38) | 0.29 (0.12–0.73) | 0.25 (0.08–0.74) | 0.69 (0.29–1.62) | ||
| Pinteraction = 0.16 | Pinteraction = 0.24 | |||||