Table 2

Age-adjusted mean of folate (geometric mean), B12, and homocyst(e)ine by case/control status and genotypes of MTR and MTHFR among the PHS participants

CaseControls
NMeanNMean
MTR genotype
 Folate
  asp/asp1264.132184.29
  gly/asp534.17873.80
  gly/gly64.60143.88
B12
  asp/asp126452218477
  gly/asp5349487476
  gly/gly654214506
 Homocyst(e)ine
  asp/asp11512.920012.3
  gly/asp4911.67911.9
  gly/gly612.81111.4
MTHFR genotype
 Folate
  ala/ala814.541384.39
  val/ala813.871164.07
  val/val143.12a463.50a
B12
  ala/ala81471138503
  val/ala81462116468
  val/val1443146440
 Homocyst(e)ine
  ala/ala7912.013512.2
  val/ala7812.311111.8
  val/val1317.6b4313.1
  • a P ≤ 0.05.

  • b P ≤ 0.01 for val/valgenotype versus ala/ala genotype.