Table 1

Frequency of MTR genotypes and age-adjusted risk of colorectal cancer by MTR genotype among participants of the Physicians’ Health Study (PHS) and the Health Professional Follow-up Study (HPFS)

MTR genotypeCasesControlsOR95% CI
N(%)N(%)
PHS
 asp/asp 145(68)235(68)1.00ref.a
 asp/gly 61(29)95(27)1.040.71–1.53
 gly/gly 6(3)16(5)0.630.24–1.64
 Total212346
HPFS
 asp/asp 103(72)82(63)1.00ref.
 asp/gly 37(26)42(32)0.710.42–1.20
 gly/gly 4(3)6(5)0.530.14–1.93
 Total144130
PHS and HPFS
 asp/asp 248(70)317(66)1.00ref.
 asp/gly 98(28)137(29)0.920.67–1.25
 gly/gly 10(3)22(5)0.590.27–1.27
 Total356476
  • a ref., reference.