Table 2

ORs according to the hOGG1 Ser326Cys polymorphism versus Ser/Ser genotype as a reference and those stratified by smoking dosage

GenotypeNo. of cases/controlsCrudeAdjusted for age and smoking habits
OR95% CIPOR95% CIP
Total
Ser/Ser85/631.001.00
Ser/Cys115/1070.800.52–1.210.2870.640.39–1.060.081
Cys/Cys41/271.130.63–2.020.6921.310.65–2.620.446
Squamous cell carcinoma
Ser/Ser40/631.001.00
Ser/Cys54/1070.800.48–1.330.3810.630.33–1.180.150
Cys/Cys24/271.400.71–2.760.3312.270.92–5.600.075
Small cell carcinoma
Ser/Ser11/631.001.00
Ser/Cys15/1070.800.35–1.860.6080.580.23–1.470.252
Cys/Cys2/270.420.09–2.050.2850.510.09–2.870.447
Adenocarcinoma
Ser/Ser25/631.001.00
Ser/Cys40/1070.940.52–1.700.8430.770.40–1.470.424
Cys/Cys13/271.210.54–2.720.6391.340.53–3.390.537
Nonadenocarcinoma
Ser/Ser57/631.001.00
Ser/Cys73/1070.750.47–1.200.2350.590.33–1.050.071
Cys/Cys28/271.150.61–2.170.6751.590.71–3.570.262
Adjusted for age
OR95% CI P
Cigarette-years <800
Ser/Ser28/381.001.00
Ser/Cys34/620.740.39–1.420.3680.740.38–1.430.362
Cys/Cys16/201.090.48–2.460.8440.970.42–2.250.943
Cigarette-years ≥800
Ser/Ser57/151.001.00
Ser/Cys81/340.630.31–1.260.1880.630.31–1.260.190
Cys/Cys25/41.650.50–5.460.4161.730.52–5.770.376