Table 4

Association between MTHFR genotype and adenomatous polyps, n = 1172a

Genotype
CC (258/303)bCT (219/269)bTT (50/73)b
All subjects (age- and sex-adjusted)1.0 (ref)0.9 (0.7–1.2)0.8 (0.6–1.3)
All subjects (multivariate adjusted)1.0 (ref)0.9 (0.7–1.2)0.8 (0.5–1.3)
Men (multivariate adjusted)1.0 (ref)1.0 (0.7–1.5)0.7 (0.4–1.3)
Women (multivariate adjusted)1.0 (ref)0.7 (0.5–1.1)1.0 (0.6–1.9)
Location of largest adenoma
 Proximal1.0 (ref)0.9 (0.6–1.5)0.9 (0.4–1.9)
 Distal1.0 (ref)0.9 (0.7–1.3)0.8 (0.5–1.4)
 Rectum1.0 (ref)0.8 (0.5–1.3)0.7 (0.3–1.6)
No. of polyps
 One1.0 (ref)1.0 (0.7–1.5)1.0 (0.5–1.7)
 Two or more1.0 (ref)0.8 (0.6–1.1)0.7 (0.4–1.3)
Agec
 <60 years1.0 (ref)0.9 (0.7–1.3)0.7 (0.4–1.2)
 ≥60 years2.4 (1.6–3.4)2.2 (1.5–3.3)2.9 (1.5–5.8)
Family history of colon cancer
 No1.0 (ref)0.9 (0.7–1.2)0.6 (0.4–1.0)
 Yes0.5 (0.3–0.9)0.5 (0.3–0.8)1.2 (0.5–2.6)
  • a Multivariate adjustment for age, sex, BMI, hormone replacement therapy (yes/no), percentage of kilocalories from fat, dietary fiber, folate, vitamin B12, vitamin B6, methionine, and alcohol.

  • b n cases/n controls.

  • c Not adjusted for age.