Table 2

Characteristics of the study population

Cases (n = 527)Controls (n = 645)Pa
Location of largest adenoma
 Proximal21%
 Distal63%
 Rectum16%
Age (yr)
 <405%13%
 40–4915%26%
 50–5932%32%
 60–6937%23%
 70+12%6%0.001
Ageb (yr)58.1 ± 9.7 (31–74)52.8 ± 10.9 (30–74)0.0001
Sex
 Men62%38%
 Women38%62%0.001
Race/Ethnicity
 White98%97%
 Other2%3%0.24
Family history of colon cancer
 Yes17%27%
 No83%73%0.001
Ever been on hormone replacement therapyc
 Yes41%52%0.004
Smoking status
 Current21%15%
 Ex-smoker46%37%
 Never33%47%0.001
Regular user of aspirin
 Yes29%32%0.031
Regular user of NSAIDsd
 Yes11%20%0.001
BMIb (kg/m2)27.3 ± 4.7 (14.4–44.9)27.0 ± 5.0 (16.3–46.2)0.22
MTHFR genotype
CC (wild-type)49%47%
CT (heterozygous)42%42%
TT (homozygous variant)10%11%0.56
  • a P based on χ2 or t test.

  • b Mean ± SD (range).

  • c Women only.

  • d NSAIDS, nonsteroidal anti-inflammatory drugs.