Clinical correlations of p16INK4a methylation in CRC in the University of California, San Francisco-University of Barcelona CRC Study
| Variable | p16INK4a status | ||||
|---|---|---|---|---|---|
| Unmethylated | Methylated | Pa | |||
| Location | |||||
| Proximal | 25/43 (58%) | 18/43 (42%) | |||
| Distal | 73/77 (95%) | 4/77 (5%) | 0.001 | ||
| Age (yrs) | 69.8 ± 11.7 | 75.8 ± 9.4 | 0.03 | ||
| Gender | |||||
| Female | 41/60 (68%) | 19/60 (32%) | |||
| Male | 57/60 (95%) | 3/60 (5%) | 0.001 | ||
| Differentiationb | |||||
| Poor | 5/12 (42%) | 7/12 (58%) | |||
| Moderate to well | 86/99 (87%) | 13/99 (13%) | 0.001 | ||
| Stage | |||||
| <Dukes’ Cc | 45/51 (88%) | 6/51 (12%) | |||
| ≥Dukes’ C | 52/68 (76%) | 16/68 (24%) | 0.10 | ||
a Ps shown are from Student’s t test for age and χ2 tests for other variables.
b Differentiation data are missing on nine subjects.
c Stage information is missing on one subject.