Table 2

Clinical correlations of p16INK4a methylation in CRC in the University of California, San Francisco-University of Barcelona CRC Study

Variablep16INK4a status
UnmethylatedMethylatedPa
Location
 Proximal25/43 (58%)18/43 (42%)
 Distal73/77 (95%)4/77 (5%)0.001
Age (yrs)69.8 ± 11.775.8 ± 9.40.03
Gender
 Female41/60 (68%)19/60 (32%)
 Male57/60 (95%)3/60 (5%)0.001
Differentiationb
 Poor5/12 (42%)7/12 (58%)
 Moderate to well86/99 (87%)13/99 (13%)0.001
Stage
 <Dukes’ Cc45/51 (88%)6/51 (12%)
 ≥Dukes’ C52/68 (76%)16/68 (24%)0.10
  • a Ps shown are from Student’s t test for age and χ2 tests for other variables.

  • b Differentiation data are missing on nine subjects.

  • c Stage information is missing on one subject.