Table 4

Stepwise regression of chlorzoxazone oral clearance on CYP2E1 RsaI genotype, dietary intake for the previous 3 days, and other covariatesa

Independent variablesbRegression coefficientPCumulative Rb
Weight (kg)1.760.00010.43
Lettuce (g/day)0.090.0020.50
Broccoli (g/day)−0.080.010.55
Black tea (g/day)−0.070.0030.61
Medicationc use (yes vs. no)0.270.0060.64
Age (yr)−0.0060.010.68
CYP2E1 genotype
 Heterozygous−0.210.03
 Homozygous variant−0.240.030.73
  • a Potential independent variables included: CYP2E1 RsaI genotype, age, sex, weight, height, ethanol, calories, total fat, saturated fat, polyunsaturated fat, cholesterol, protein, non-starch polysaccharides, vitamin A, total carotenoids, coffee, black tea, green tea, broccoli, cabbage, radish, watercress, spinach, cilantro, mustard green, lettuce, tomato, celery, carrot, cucumber, soy products, garlic, onion, apple, grapes, grapefruit, orange, lemon/lime, papaya, banana, red meat, processed meats, acetaminophen use, supplement use, and other medication use.

  • b Variables are listed in order of entry into the stepwise regression.

  • c Other than acetaminophen.