Table 2

Geometric meana (and 95% confidence interval) for CYP2E1 activity as assessed by the oral clearance (ml/min) of chlorzoxazone according to the CYP2E1 RsaI genotype

c1/c1c1/c2c2/c2Pb
1 vs. 31 vs. 22 vs. 3
All238 (193–293)201 (166–243)147 (115–188)0.0040.240.05
Male234 (186–296)210 (163–271)171 (127–231)0.070.320.36
Female227 (160–321)195 (156–244)118 (85–164)0.030.490.03
  • a Adjusted for age, and sex when appropriate, by multiple covariance analysis. See Table 1<$REFLINK> for numbers of subjects.

  • b Ps for differences between genotypes (1, c1/c1; 2, c1/c2; 3, c2/c2).