Table 1

p53 mutations in relation to some characteristics among 243 lung cancer cases diagnosed 1980–1984 in Sweden

No. of subjects with p53 mutationaTotal no. of subjects
Sex
 Female20 (19.2)104
 Male38 (27.3)139
Age
 <60 years8 (15.1)53
 60–69 years39 (30.7)127
 >69 years11 (17.5)63
Histology
 Small cell carcinoma24 (32.9)73
 Squamous cell carcinoma19 (32.2)59
 Adenocarcinoma12 (14.0)86
 Other3 (12.0)25
Radon exposure
 ≤50 Bq/m329 (20.9)139
 >140 to 400 Bq/m323 (25.6)90
 >400 Bq/m36 (42.9)14
Smoking status
 Never smoked9 (13.8)65
 Current smoker <10 cigarettes/day26 (37.7)69
 Current smoker ≥10 cigarettes/day23 (21.1)109
Occupationb
 Low risk4 (28.6)14
 Medium risk36 (24.8)145
 High risk17 (22.7)75
 Unknown1 (11.1)9
Urban dwellersc
 Yes7 (22.6)31
 No51 (24.1)212
Total58 (23.9)243
  • a Per cent in each category after SSCP analysis and sequence analyses.

  • b The occupation of each subject was classified into one of four categories based on earlier evidence of occupational risks of lung cancer. Subjects working for 2 years or more in a job assigned to either of the two highest-risk categories were considered to have a high risk; those working only in jobs assigned to the category with lowest risk were considered to have a low risk; and the remaining were considered to have a medium risk.

  • c Subjects who lived for 10 years or more in any of the three largest cities in Sweden (Stockholm, Göteborg, or Malmö) at some time between 1947 and the end of follow-up were classified as urban dwellers.