Table 1

Clinical profile of female nonsmokers and smokers with lung cancer whose tumors were analyzed for mutations

NonsmokersSmokers
Number of cases2332
Mean age ± SE (yrs)57.8 ± 23.761.0 ± 19.5
Histology of tumor
 Adenocarcinoma12 (52.2%)14 (43.8%)
 Adenosquamous2 (8.7%)1 (3.1%)
 Bronchioloalveolar4 (17.4%)0
 Squamous cell4 (17.4%)12 (37.5%)
 Large cell1 (4.3%)3 (9.4%)
 Small cell01 (3.1%)
 Neuroendocrine01 (3.1%)
Stage at diagnosis
 I13 (56.5%)16 (50%)
 II2 (8.7%)8 (25%)
 IIIa or IIIb3 (13.0%)7 (21.9%)
 IV4 (17.4%)0
 Unknown1 (4.3%)1 (3.1%)
PY smoking
 0230
 <1002
 10–2501
 26–50016
 >50013
Environmental tobacco smoke exposure
 Yes3n/a
 No1n/a
 Unknown19n/a
Cases with K-ras mutation2 (8.7%)8 (25%)
Cases with p53 mutation6 (26.1%)10 (31.3%)
Cases with either mutation8 (34.8%)18 (56.3%)