Table 3

Age-adjusted ORs and 95% CIs for p53+ and p53− breast cancer in relation to known and suspected breast cancer risk factors among women under the age of 45 years in New Jersey, 1990–1992

Controls (n = 462)p53+ cases (n = 168)p53− cases (n = 210)p53+ age-adjusted OR (95% CI)p53− age-adjusted OR (95% CI)Ratio of the ORs (95% CI)
Environmental factors
 Cigarette smoking
  Never248811091.01.0
  Former10044581.33 (0.86–2.06)1.30 (0.88–1.94)1.02 (0.63–1.66)
  Current11343431.18 (0.77–1.83)0.87 (0.57–1.33)1.36 (0.81–2.26)
 Alcohol use (drinks/week)
  None19772731.01.0
  <7227771190.93 (0.64–1.35)1.41 (1.00–2.00)0.66 (0.43–1.01)
  ≥73819181.38 (0.75–2.56)1.30 (0.70–2.44)1.06 (0.51–2.18)
 Electric blanket and mattress pad use
  Never3251001461.01.0
  Ever13768641.59 (1.10–2.30)1.02 (0.72–1.47)1.55 (1.01–2.38)
 Electric blanket and mattress pad use (in months)
  Never3251001461.01.0
  1–94123181.79 (1.03–3.14)0.96 (0.53–1.73)1.87 (0.96–3.65)
  10–294620241.41 (0.79–2.49)1.16 (0.68–1.97)1.21 (0.64–2.32)
  ≥305025221.60 (0.94–2.72)0.96 (0.56–1.65)1.66 (0.89–3.11)
Reproductive factors
 OC use
  Never-<0.5 year16855711.01.0
  0.5–5 years17666861.13 (0.75–1.72)1.14 (0.78–1.67)1.00 (0.62–1.60)
  5–9 years8130341.14 (0.68–1.92)1.02 (0.62–1.66)1.12 (0.61–2.05)
  ≥10 years3717191.47 (0.76–2.82)1.27 (0.68–2.37)1.15 (0.55–2.42)
 Parity
  Ever parous3611331641.01.0
  Never parous10135461.03 (0.66–1.61)1.15 (0.77–1.73)0.89 (0.54–1.49)
 Age at first birth (each additional year)1.03 (0.99–1.07)1.04 (1.00–1.08)0.99 (0.95–1.04)
 Children (among parous women)
  19233381.01.0
  216164801.08 (0.66–1.77)1.17 (0.74–1.87)0.92 (0.52–1.64)
  ≥310836460.89 (0.51–1.56)0.98 (0.58–1.65)0.91 (0.48–1.74)
 Lactation (among parous women)
  Never17971791.01.0
  Ever17761850.95 (0.63–1.43)1.24 (0.85–1.81)0.77 (0.48–1.23)
 Induced abortion (among gravid women)
  Never3051151371.01.0
  Ever10037381.05 (0.68–1.61)0.81 (0.54–1.24)1.29 (0.78–2.14)
 Age at menarche (yr)
  8–12230861271.01.0
  ≥1323282830.93 (0.65–1.32)0.65 (0.46–0.90)1.43 (0.95–2.17)
Energy balance
 Body Size (BMI)a
  <2314466811.01.0
  23–2614953550.79 (0.51–1.21)0.67 (0.44–1.01)1.18 (0.72–1.94)
  ≥2714243710.66 (0.42–1.03)0.88 (0.59–1.31)0.74 (0.45–1.22)
Physical activity (average of three time periods, relative units in quartiles)
  1 (low)11343471.01.0
  211943540.98 (0.60–1.62)1.15 (0.72–1.84)0.86 (0.48–1.53)
  311538540.91 (0.55–1.52)1.20 (0.75–1.93)0.76 (0.42–1.37)
  4 (high)11544551.06 (0.64–1.74)1.23 (0.77–1.98)0.86 (0.48–1.53)
 Caloric intake (Kcal, in quartiles)
  <110011233411.01.0
  1100–145011337661.18 (0.69–2.02)1.69 (1.06–2.73)0.69 (0.38–1.28)
  1450–183011241411.32 (0.78–2.25)1.07 (0.64–1.79)1.23 (0.65–2.32)
  ≥183011252571.71 (1.02–2.87)1.54 (0.95–2.50)1.11 (0.61–2.02)
 Dietary fatb intake (grams, in quartiles)
  <43.911439561.01.0
  43.9–<58.211134510.74 (0.40–1.41)0.68 (0.39–1.18)1.11 (0.55–2.24)
  58.2–<79.111238420.73 (0.35–1.52)0.56 (0.29–1.07)1.31 (0.58–2.97)
  ≥79.111252560.88 (0.37–2.09)0.70 (0.31–1.56)1.26 (0.47–3.35)
 Fruit consumptionb (average weekly servings, in quartiles)
  <2.112842481.01.0
  2.1–<4.912534540.84 (0.50–1.42)1.25 (0.78–1.99)0.68 (0.37–1.23)
  4.9–<9.19347441.47 (0.89–2.42)1.24 (0.75–2.02)1.19 (0.66–2.14)
  ≥9.110340591.13 (0.68–1.90)1.52 (0.95–2.43)0.75 (0.42–1.34)
Vegetable consumptionb (average weekly servings, in quartiles)
  <9.112537521.01.0
  9.1–<13.311340471.11 (0.66–1.86)0.95 (0.59–1.53)1.16 (0.64–2.13)
  13.3–<19.610747481.34 (0.80–2.25)0.99 (0.61–1.62)1.35 (0.74–2.45)
  ≥19.610439581.08 (0.63–1.86)1.22 (0.76–1.96)0.89 (0.48–1.63)
Other factors
 Family history of breast cancer
  None4311371831.01.0
  First degree3131273.05 (1.78–5.21)1.94 (1.12–3.35)1.57 (0.89–2.76)
 Previous biopsy
  None4401521861.01.0
  ≥12216242.00 (1.02–3.92)2.48 (1.35–4.55)0.81 (0.41–1.58)
 Education
  HS/Tech16040831.01.0
  Some college11655421.96 (1.22–3.15)0.72 (0.46–1.13)2.71 (1.56–4.70)
  College graduate18673851.65 (1.06–2.58)0.92 (0.63–1.33)1.80 (1.10–2.95)
 Race
  Whites3821351851.01.0
  Blacks4821181.24 (0.72–2.16)0.77 (0.44–1.37)1.61 (0.83–3.15)
  Asian/Other321271.08 (0.54–2.16)0.47 (0.20–1.08)2.30 (0.88–6.01)
  • a BMI, body mass index; HS/Tech, high school or technical school.

  • b Dietary variables adjusted for both age and caloric intake.