Table 2

Risk of postmenopausal breast cancer by CYP1A1 polymorphism and PCB body burden, Western New York 1986–1991

PCB/CYP1A1CaseControlCrude OR95% CIAdj. ORa95% CI
PCB lowb-Ile:Ile62 (41)85 (45)1.01.0
PCB lowb-Ile:Val/Val:Val8 (5)11 (6)1.00.37–2.620.880.29 –2.70
PCB highc-Ile:Ile65 (42)83 (43)1.070.68 –1.701.080.62 –1.89
PCB highc-Ile:Val/Val:Val19 (12)12 (6)2.170.98 –4.782.91.18 –7.45
Total154 (45)191 (55)
  • a ORs adjusted for age, education, serum lipids, age at menopause, family history of breast cancer, age at first birth, parity, duration of lactation, body mass index, and smoking status homozygous (Ile:Ile) for the CYP1A1 wild-type alleles.

  • b 0.75–3.72 ng/g of serum.

  • c 3.73–19.04 ng/g of serum.