Table 7

Cigarette smoking and imputed NAT2 phenotype: multivariate-adjusteda ORs (95% CI) for various polyp pathology characteristics versus controls

Polyp characteristicsSmoking statusP-interaction
Never-smokerEx-smokerCurrent smokerSlopes (1 df)bNAT2 × smoking (2 df)b
Hyperplastic polyp
 Slow1.02.6 (1.5–4.3)3.9 (2.1–7.1)0.820.81
 Intermediate/fast1.1 (0.6–2.1)2.5 (1.4–4.4)4.9 (2.6–9.4)
Adenoma
 Slow1.01.5 (1.0–2.2)2.0 (1.2–3.2)0.970.87
 Intermediate/fast1.1 (0.7–1.7)1.5 (1.0–2.2)2.3 (1.4–3.9)
Multiple adenomas
 Slow1.01.5 (0.8–2.7)2.5 (1.2–5.2)0.440.76
 Intermediate/fast1.1 (0.6–2.3)1.9 (1.1–3.5)4.3 (2.1–8.8)
≥1 cm adenoma
 Slow1.01.9 (1.1–3.4)2.4 (1.2–4.8)0.730.28
 Intermediate/fast1.2 (0.6–2.3)1.5 (0.8–2.7)3.8 (1.9–7.5)
Tubulovillous adenoma
 Slow1.01.9 (1.1–3.3)2.6 (1.3–4.9)0.510.41
 Intermediate/fast1.2 (0.6–2.2)1.3 (0.7–2.3)2.4 (1.2–5.0)
  • a Adjusted for age, sex, nonsteroidal anti-inflammatory drug use, hormone replacement therapy use.

  • b df, degree(s) of freedom.