Table 3

Lung cancer riska associated with cigarette smoking by GSTM1 genotype according to intervention group, ATBC Study, Finnish men

GroupGenotypeYears of smoking tertileP-trendb
<3737–42>42
OR (95% CI)a No. of cases/controlsOR (95% CI)a No. of cases/controlsOR (95% CI)a No. of cases/controls
All subjectsGSTM1 present1.00 (reference)1.15 (0.62–2.14)1.85 (0.85–4.02)0.002
41/5256/6554/62
GSTM1 null1.00 (reference)3.77 (1.98–7.16)6.28 (2.70–14.63)0.0001
33/6953/4469/49
α-Tocopherol
 NOGSTM1 present1.00 (reference)2.41 (0.98–5.92)2.37 (0.79–7.15)0.003
18/3129/2428/29
GSTM1 null1.00 (reference)6.78 (2.69–17.11)21.15 (6.26–72.69)0.0001
13/4435/2945/21
 YESGSTM1 present1.00 (reference)0.60 (0.24–1.46)1.33 (0.43–4.18)0.29
23/2127/4134/25
GSTM1 null1.00 (reference)2.20 (0.85–5.74)1.34 (0.36–5.03)0.28
20/2523/1524/28
β-carotene
 NOGSTM1 present1.00 (reference)1.19 (0.48–2.92)1.19 (0.40–3.58)0.22
18/2229/2826/24
GSTM1 null1.00 (reference)3.38 (1.32–8.66)8.17 (2.24–29.82)0.004
20/3922/2227/21
 YESGSTM1 present1.00 (reference)1.35 (0.56–3.26)3.56 (1.14–11.12)0.001
23/3027/3736/30
GSTM1 null1.00 (reference)4.78 (1.91–11.92)6.01 (1.90–19.08)0.001
13/3036/2242/28
  • a OR and 95% CI after adjusting for age, daily cigarettes smoked, and intervention assignment.

  • b P for trend based upon the P (two-sided) of years smoked modeled as a continuous term.