Appendix

NAT2 imputed phenotypes and corresponding genotypes among colon cancer cases and population-based controls

NAT 2 imputed phenotypes and genotypesMen, n (%)Women, n (%)
CasesControlsCasesControls
Mutant/mutant: slow536603394553
NAT2*5A/*5A 1 (0.2) 0 1 (0.2) 1 (0.2)
NAT2*5A/*5B,C 14 (2.6) 20 (3.3) 21 (5.3) 21 (3.8)
NAT2*5A/*6A,B 15 (2.8) 13 (2.2) 10 (2.5) 11 (2.0)
NAT2*5A/*7A,B 2 (0.4) 1 (0.2) 0 2 (0.4)
NAT2*5B,C/*5B,C168 (31.3)192 (31.8)118 (30.0)157 (28.4)
NAT2*5B,C/*6A,B119 (42.7)242 (40.1)168 {42.6)212 (38.3)
NAT2*5B,C/*7A,B 20 (3.7) 33 (5.5) 9 (2.3) 28 (5.1)
NAT2*6A,B/*6A,B 63 (11.7) 85 (14.1) 51 (12.9)103 (18.6)
NAT2*6A,B/*7A,B 17 (3.2) 12 (0.2) 12 (3.1) 11 (2.0)
NAT2*7A,B/*7A,B 1 (0.2) 3 (0.5) 1 (0.2) 0
NAT2*14/*14 1 (0.2) 0 1 (0.2) 0
NAT2*14/*5A 0 0 0 0
NAT2*14/*5B,C 2 (0.4) 1 (0.2) 0 4 (0.7)
NAT2*14/*6A,B 3 (0.6) 1 (0.2) 2 (0.5) 3 (0.5)
NAT2*14/*7A,B 0 0 0 0
Wild type/mutant: intermediate323361281322
NAT2*4/*5A 6 (1.9) 14 (3.9) 12 (4.3) 12 (3.7)
NAT2*4/*5B,C166 (51.4)200 (55.4)152 (54.1)180 (55.4)
NAT2*4/*6A,B129 (39.9)124 (34.3) 88 (31.3)111 (34.5)
NAT2*4/*7A,B 7 (2.2) 9 (2.5) 10 (3.6) 9 (2.8)
NAT2*4/*14 2 (0.6) 0 1 (0.4) 0
NAT2*12A,B/*5A 0 0 0 0
NAT2*12A,B/*5B,C 4 (1.2) 7 (1.9) 10 (3.6) 4 (1.2)
NAT2*12A,B/*6A,B 7 (2.2) 6 (1.9) 6 (2.1) 5 (1.6)
NAT2*12A,B/*7A,B 1 (0.3) 1 (0.3) 2 (0.7) 1 (0.3)
NAT2*12A,B/*14 1 (0.3) 0 0 0
Wild type/wild type: rapid 53 72 37 52
NAT2*4/*4 49 (92.5) 64 (88.9) 31 (83.8) 41 (86.5)
NAT2*12A,B/*12A,B 0 1 (1.4) 0 0
NAT2*4/*12A,B 4 (7.5) 7 (9.7) 6 (16.2) 7 (13.5)