Table 4

Comparison of HPV-16 serological assays as screening tests for invasive cervical cancer

AssaySensitivitySpecificity
HPV-16 VLP antibodies47.475.6
HPV-16 E6 or E7 antibodiesa63.489.9
HPV-16 VLP or E6 or E7 antibodies80.268.7
HPV-16 VLP or E6 or E7 antibodies (high titers)b53.693.6
  • a These data were reported previously (8).

  • b For E6 and E7 antibodies ≥6000 cpm, for VLP antibodies ≥A 0.400.