Table 2

Description of association studies of genetic polymorphisms and breast cancer risk

AuthorsCountryCasesControlsEthnic groupCommentsGenes studied
nSourceAge (years)nSourceAge (years)
Agundez et al. 1995 (19)Spain160NSa26–87132NS19–81White Spanish NAT2
Ambrosone et al. 1995 (20)USA177PPost-men233PPost-men CYP1A1
Ambrosone et al. 1996 (21)USA119HPre-men114PPre-menNS NAT2
185HPost-men213PPost-men
Andersen et al. 1994 (22)Norway191H27–94204PNSNSVarious sources of male and female controls used ER
Bailey et al. 1998 (23)USA164HNS162NSNSCaucasianControls matched on age CYP1A1, GSTM1
59HNS59NSNSAfrican-AmericanGSTT1
Buchert et al. 1993 (24)USA167H29–80114H25–61Caucasian CYP2D6
Campbell et al. 1996 (25)UK208NSNS113NSNSNS P53
Charrier et al. 1999 (26)France361P26–80437P18–101Caucasian GSTM1
Chouchane et al. 1997 (27)Tunisia40HMean = 43106PMean = 39Controls were healthy blood donorsTNF-α, HSp-70
Dunning et al. 1997 (28)UK212H<70277P45–70CaucasianEast-Anglian case-control series BRCA1
268P<36UK case-control study
321P36–45353P36–45UK case-control study
Dunning et al. 1998 (29)UK835P<55591P45–75>90% Caucasian CYP17
Feigelson et al. 1997 (30)USA174P45–75285P45–75Asian, Latino, African AmericanNested case-control study CYP17
Garrett et al. 1995 (31)Ireland187NSNS90NSNSNS PR
Haiman et al. 1999 (32)USA464PNS619PNSCaucasianNested case-control study within the Nurses’ Health Study CYP19
Harries et al. 1997 (33)Scotland62H37–82155HNSCaucasian GSTP1
Helzlsouer et al. 1998 (34)USA110PMean = 60113PMean = 60NSNested case-control study, controls matched for age, race, and menopausal status GSTM1, GSTP1, GSTT1
Helzlsouer et al. 1998 (35) COMT
Lavigne et al. 1997 (39) CYP17
Hunter et al. 1997 (40) Ishibe et al. 1998 (41)USA466PMean = 61466PMean = 61NSNested case-control study using incident cases from the Nurses’ Health Study. Controls matched on age, menopausal status, and postmenopausal hormone use NAT2, CYP1A1
Huober et al. 1991 (36)Germany108H20–80123H20–80NSPhenotype study. Controls were patients with benign breast disease CYP2D6
Iwase et al. 1996 (42)UK70HNS30NSNSNS ER
Kawajiri et al. 1993 (43)Japan93HNS347NSNSJapanese p53
Kelsey et al. 1997 (44)USA245PNS245PNS>95% CaucasianPrevalent cases GSTM1
240P240PIncident cases
Nested case-control study within Nurses’ Health Study. Controls matched on age and menopausal status
Kristensen et al. 1998 (37)Norway/ Sweden366H27–93252PH1–85NS172 controls from Norwegian population register; 80 Swedish controls from genetic counseling clinic CYP19
Ladero et al. 1991 (45)Spain98HMean = 59446NSMean = 25NSPhenotype study CYP2D6
Ladona et al. 1996 (46)Spain187H26–87151NS18–83White Spanish CYP2D6
Lancaster et al. 1998 (38)USA68HNS101HNSNS PR