Table 1

Genotype frequencies of CYP3A4 wild-type (A) and variant (G) in men, across ethnic groups and among African-American healthy volunteers and prostate cancer patients

GroupGenotype frequencyb
naAAAGGGPc
Asiand801.00<0.0001
Caucasian1170.930.060.01<0.0001
Hispanic1210.800.180.02<0.0001
African Americans
 Healthy volunteers1160.190.530.28 c
 Prostate cancer patients1740.170.370.460.005
0.002e
  • a n, number of subjects.

  • b A, wild type; G, variant.

  • c Two-sided P from Pearson χ2 tests comparing frequencies in each group with frequencies in African-American healthy volunteers. Among African Americans, P from a comparison of healthy volunteers and prostate cancer cases.

  • d Asian includes Chinese-American (n = 46) and Japanese-Americans (n = 34) subjects.

  • e P comparing GG versus AA and AG combined.