Table 3

Supplemental vitamin E and the multivariate RRa of total, extraprostatic, and metastatic or fatal prostate cancer by smoking habits in 1986

Supplemental vitamin E (IU/day)b
00.1–15.015.1–99.9≥100.0
Total non-A1 cases (n = 1896)
 Never-smokers (n = 819)1.001.050.931.02
(0.83–1.32)(0.75–1.15)(0.86–1.21)
 Quit ≥10 years ago (n = 708)1.001.070.971.04
(0.83–1.37)(0.78–1.22)(0.86–1.26)
 Current smoker/quit within past 10 years (n = 369)1.001.230.971.27
(0.88–1.70)(0.72–1.32)(0.97–1.66)
Extraprostatic cases (n = 522)c
 Never-smokers (n = 213)1.001.021.211.45
(0.63–1.64)(0.81–1.81)(1.05–2.02)
 Quit ≥10 years ago (n = 193)1.001.571.341.15
(1.03–2.40)(0.89–2.00)(0.80–1.68)
 Current smoker/quit within past 10 years (n = 110)1.000.720.761.00
(0.37–1.40)(0.43–1.34)(0.61–1.64)
Metastatic/fatal cases (n = 232)c
 Never-smokers (n = 97)1.000.911.291.42
(0.44–1.88)(0.72–2.29)(0.87–2.32)
 Quit ≥10 years ago (n = 78)1.002.431.331.49
(1.32–4.47)(0.67–2.64)(0.82–2.69)
 Current smoker/quit within past 10 years (n = 55)1.000.780.510.44
(0.34–1.77)(0.21–1.21)(0.18–1.07)
  • a Multivariate relative risks (RRs) adjusted for period (1986–1987, 1988–1989, 1990–1991, 1992–1993, and 1994–1995), age (nine 2.5-year categories), family history of prostate cancer (father or brother), vasectomy status (ever or never through 1994), quintiles of current body mass index, body mass index at age 21 years and physical activity in 1986 (metabolic hours/week), and quintiles of total calories, calcium, lycopene, fructose, and fat intake per day in 1986.

  • b Numbers in parentheses are 95% CIs.

  • c Case totals do not sum because six cases of extraprostatic and two cases of metastatic or fatal prostate cancer were dropped during analysis due to missing data on one of the covariates.