Table 2.

Association between ACS guidelines score and mortality from all causes, CVD, or cancer

ACS guidelines scoreMenWomen
Deaths (n)Person- yearsRR (95% CI)aPtrendbDeaths (n)Person- yearsRR (95% CI)aPtrendb
All-cause mortality
 0–2, referent1,52476,6931.00 (-)93093,0771.00 (-)
 31,736100,1480.83 (0.78–0.89)1,216125,4270.92 (0.85–1.00)
 42,161134,2360.75 (0.70–0.80)1,373166,2350.76 (0.69–0.82)
 52,156139,9490.70 (0.65–0.74)1,373179,2680.68 (0.62–0.74)
 61,613108,9620.66 (0.61–0.71)1,001139,5050.63 (0.58–0.69)
 7, 81,17990,3920.58 (0.53–0.62)<0.0001720109,5940.58 (0.52–0.64)<0.0001
CVD mortality
 0–2, referent533-1.00 (-)294-1.00 (-)
 3634-0.86 (0.76–0.96)394-0.92 (0.79–1.07)
 4780-0.74 (0.67–0.83)399-0.66 (0.57–0.77)
 5785-0.69 (0.62–0.77)410-0.60 (0.52–0.70)
 6540-0.60 (0.53–0.67)287-0.54 (0.45–0.63)
 7, 8394-0.52 (0.45–0.59)<0.0001178-0.42 (0.35–0.51)<0.0001
Cancer mortality
 0–2, referent496-1.00 (-)340-1.00 (-)
 3555-0.85 (0.75–0.96)421-0.90 (0.78–1.04)
 4649-0.73 (0.65–0.83)540-0.85 (0.74–0.98)
 5673-0.73 (0.65–0.82)501-0.72 (0.63–0.83)
 6529-0.73 (0.65–0.83)429-0.79 (0.68–0.91)
 7, 8416-0.70 (0.61–0.80)<0.0001325-0.76 (0.65–0.89)<0.0001
Cancer mortality, alternate scoring for alcohol consumption componentc
 0–2 (referent)53987,0611.00 (-)27775,2141.00 (-)
 3599111,5490.86 (0.76–0.96)403118,9710.90 (0.77–1.05)
 4724144,0210.80 (0.71–0.89)537178,2060.80 (0.69–0.93)
 5668140,8430.75 (0.67–0.84)581186,7220.81 (0.70–0.93)
 6493105,0290.73 (0.65–0.83)442149,8210.76 (0.65–0.88)
 7, 829561,8770.75 (0.65–0.87)<0.0001316104,1720.78 (0.67–0.92)0.0004
  • aRelative risk and 95% CI. Multivariate model adjusted for age, smoking status [never, years since quitting (≤5, >5–10, >10–15, >15–20, >20–25, >25, unknown] and education (less than high school/high school graduate/some college or trade school/college graduate).

  • bP value for trend calculated by assigning an ordinal value to each category and modeling as a continuous variable.

  • cAlcohol consumption component scored as: heavy drinkers = 0, moderate drinkers = 1, and nondrinkers = 2.