Table 5.

ORs and 95% CIs by inflammatory profile

Cytokine vs. modulatorLow/lowLow/highHigh/lowHigh/high
IL-1β vs. IL-1Ra
No. of cases/controls72/13939/8542/7177/137
OR (95% CI)1.0 (ref)0.91 (0.57–1.47)1.15 (0.71–1.85)1.09 (0.73–1.64)
P value0.710.570.67
IL-1β vs. sIL-1Rll
No.of cases/controls46/10565/11970/10949/99
OR (95% CI)1.0 (ref)1.20 (0.76–1.92)1.43 (0.90–2.27)1.11 (0.68–1.81)
P value0.430.130.69
IL-2 vs. sIL-2Ra
No. of cases/controls48/11859/10763/9960/108
OR (95% CI)1.0 (ref)1.36 (0.85–2.19)1.56 (0.98–2.47)1.36 (0.85–2.16)
P value0.200.060.20
IL-4 vs. sIL-4R
No. of cases/controls61/12144/10353/9572/113
OR (95% CI)1.0 (ref)0.85 (0.53–1.36)1.11 (0.70–1.76)1.28 (0.84–1.97)
P value0.500.650.25
IL-6 vs. sIL-6R
No. of cases/controls52/11651/11068/9459/112
OR (95% CI)1.0 (ref)1.05 (0.66–1.68)1.65 (1.05–2.61)1.19 (0.76–1.89)
P value0.840.030.45
IL-12p70 vs. IL-12p40
No. of cases/controls49/12954/10058/9669/107
OR (95% CI)1.0 (ref)1.46 (0.92–2.34)1.62 (1.01–2.58)1.74 (1.11–2.74)
P value0.110.040.02
TNFα vs. sTNF-R1
No. of cases/controls48/13767/8362/8563/127
OR (95% CI)1.0 (ref)2.12 (1.30–3.45)2.13 (1.33–3.41)1.51 (0.95–2.41)
P value0.0020.0020.08
TNFα vs. sTNF-R2
No. of cases/controls62/12943/9153/8672/126
OR (95% CI)1.0 (ref)0.98 (0.61–1.58)1.28 (0.81–2.03)1.18 (0.76–1.82)
P value0.940.290.46

NOTE: Each marker was classified as high or low on the basis of the median value and then 4 groups were created for each pair. Models are unconditional logistic regression models, adjusted for the matching factors (age, cohort, and menopausal status).