Table 2.

Significant interactions at 5% level between known CRC-associated variants and environmental factors

SNPChrGeneMAF aMain SNP effect OR (95% CI)Environment factorCategoryStratified OR (95% CI)P-int bReplication sample: ARCTIC Study
Stratified OR (95% CI)P-int b
rs168927668q23.3EIF3H (flanking 3′ end)0.081.28 (1.01–1.62)
rs69832678q24.21POU5F1B (flanking 5′ end)0.480.81 (0.70–0.93)
rs70143468q24.21POU5F1B (flanking 5′ end)0.381.17 (1.02–1.34)
rs70252959p24.1UHRF2 (flanking 5′ end)0.400.83 (0.73–0.96)
rs78576289p24.1UHRF2 (flanking 5′ end)0.410.82 (0.71–0.94)
rs10795668 c10p14Gene desert0.330.84 (0.73–0.98)OC useNo0.97 (0.70–1.34)0.040.97 (0.71–1.32)0.30
Yes0.61 (0.46–0.81)1.23 (0.92–1.65)
rs380284211q23.1C11orf93 (intron)0.281.22 (1.06–1.41)PMH useNo1.48 (1.11–1.98)0.011.08 (0.80–1.47)0.53
Yes0.79 (0.56–1.11)1.24 (0.91–1.68)
rs444423514q22.2BMP4 (flanking 3′ end)0.481.11 (0.97–1.26)
rs477958415q13.3SCG5 (flanking 3′ end)0.191.22 (1.03–1.44)
rs992921816q22.1CHD1 (intron)0.290.93 (0.80–1.08)Height<1.7 m1.13 (0.91–1.41)0.020.79 (0.62–0.99)0.58
≥1.7 m0.79 (0.65–0.97)0.72 (0.57–0.90)
Calcium useNo0.85 (0.72–1.02)0.050.78 (0.64–0.96)0.55
Yes1.21 (0.89–1.64)0.70 (0.53–0.93)
Alcohol useNo1.04 (0.87–1.25)0.040.66 (0.49–0.88)0.30
Yes0.74 (0.56–0.96)0.79 (0.65–0.97)
rs493982718q21.1SMAD7 (intron)0.480.80 (0.70–0.92)Vegetable intake<14 p/wk0.84 (0.68–1.04)0.010.79 (0.62–0.99)0.33
≥14 p/wk0.77 (0.65–0.93)0.91 (0.75–1.10)
rs1041121019q13.11RHPN2 (intron)0.091.02 (0.81–1.28)
rs96125320p12.3Gene desert0.351.02 (0.89–1.18)OC useNo1.48 (1.07–2.06)0.011.16 (0.86–1.57)0.22
Yes0.83 (0.64–1.09)0.90 (0.67–1.20)

Abbreviations: PMH, postmenopausal hormones; OC, oral contraceptives; –, no G × E interaction detected at significance level less than 5% for the selected environmental factors.

  • aMAF determine in unrelated controls.

  • bP-value for interaction between G and E.

  • crs7894531 used as proxy for rs10795668 (r2 = 0.892) in replication sample, ARCTIC Study.