Table 2.

Analysis of the resected tumors for MET copy number (FISH), mRNA (PCR), MET protein expression (IHC), and phosphorylation status (p-MET IHC)

FISH copy ratio of MET/CEP17 (n = 38)Relative MET mRNA expression (median 5.5, n = 14a)IHC
MET (n = 38)p-MET (n = 30)
3 to 5/3 to 52+0
2/29.91+Luminal
2/21+1+
2/22+
2/214.41+
2/211.42–3+1+
2/21+0
2/21.92+0
2/23.12+ (10%)Luminal
3/30
2/22+0
2/22+1+
3 to 8/3 to 83.32+2+
3 to 4/3 to 4 in 5% cells34.22–3+0
2/21+1+
2/252.42+0
2/22.32+
2/22+
3 to 4/3 to 45.22+
2/22+1+
2/214.42+
3 to 6/3 to 62+0
2/25.92+0
2/22.11+0
2/24.21+0
3 to 4/3 to 42+0
2/22+1+ focal
3 to 5/3 to 51+0
2/21+
3 to 4/3 to 4 in 3% cells2+Luminal
2/21+2+
2/22+Luminal
3 to 5/3 to 52+Luminal
2/22+0
2/21+1+
2/22+1+ focal
2/21+0
3 to 5/3 to 52+0

aIncludes only surgical specimens.