Table 1.

Baseline characteristics of incident colorectal adenoma cases and matched controls in the PLCO trial

CharacteristicCasesControlsPa
(n = 356)(n = 396)
Age, y62.7 (5.0)62.8 (5.0)Matched
Female, %34.834.6Matched
Caucasian, %89.690.4Matched
Family history of colorectal cancer, %12.17.80.05
Some college education and above, %71.070.00.77
Diabetes, %6.47.00.74
BMI at baseline, kg/m227.4 (4.5)27.2 (4.6)0.36
Hours spent in vigorous physical activity per week, %
 015.011.00.55
 1–230.030.0
 ≥355.059.0
Cigarette smoking status
 Never, %45.051.00.18
 Current, %9.07.0
 Former, %46.043.0
Ever use of female hormone therapy, %b59.054.00.81
Use of NSAIDs, %54.061.00.29
Daily intake
 Alcohol, g15.2 (26.4)11.4 (26.7)0.03
 Folate, μg399 (200)403 (199)0.73
 Red meat, g89.7 (73.6)81.6 (68.9)0.37
 Energy, kcal2,197 (866)2,229 (930)0.94
 Saturated fat, g24.1 (12.3)24.5 (14.7)0.47
 Fiber, g23.9 (12.3)24.6 (14.8)0.37
 Calcium, mg997 (544)1,026 (590)0.91
CRP, mg/Lc1.6 (0.3–3.0)1.8 (0.1–3.4)0.29
Adenoma characteristics
Advanced adenoma (n)143
 Non-advanced adenoma144
 Unknown69
Multiple adenomas present (n)55
 Non-multiple adenomas274
 Unknown27
Adenoma Locationd (n)
 Colon305
 Rectum90
Follow-up year when adenoma detected (n)
 Year 3109
 Year 5247

Values are means (SD) unless otherwise stated.

  • aP-values derived from t test for continuous data and Pearson's chi-square for categorical data.

  • bIn females only.

  • cMedian levels (and inter-quartile range).

  • dTotal number exceeds 396 due to presence of multiple adenomas for some subjects.