Table 2.

Serum fatty acids by p53 immunoreactivity expressed as proportion of p53-positive cells in the whole epidermis (mean and 95% CI) by tertile group of serum fatty acids; Nambour Skin Cancer Prevention Trial, Australia

Fatty acidTertile 1Tertile 2Tertile 3Pa
Total n-3b, μg/mL36.7 (20.7–43.6)50.2 (43.8–55.8)67.1 (55.9–112.2)
 % Basicc10.6 (7.0–16.1)7.6 (5.2–10.9)5.5 (3.9–7.8)0.03
 % Multivariabled14.0 (8.0–24.5)8.1 (4.8–13.6)6.1 (3.9–9.6)0.006
ALA, μg/mL1.2 (0.5–1.5)1.8 (1.5–2.2)2.9 (2.2–5.2)
 % Basic7.1 (4.7–10.7)6.5 (4.4–9.4)7.7 (5.3–11.1)0.78
 % Multivariable7.2 (4.1–12.6)7.0 (4.1–11.9)8.2 (5.0–13.3)0.83
EPA, μg/mL6.5 (2.7–8.0)10.1 (8.1–12.2)14.8 (12.3–32.6)
 % Basic9.4 (6.2–14.4)7.8 (5.3–11.5)5.7 (4.0–8.2)0.15
 % Multivariable11.2 (6.6–19.3)7.8 (4.7–12.8)6.0 (3.6–10.0)0.06
DHA, μg/mL26.7 (16.0–31.7)37.7 (32.0–42.1)52.1 (42.2–77.4)
 % Basic9.2 (6.1–14.0)6.7 (4.6–9.7)6.4 (4.5–9.2)0.27
 % Multivariable13.3 (7.2–22.6)7.4 (4.5–12.2)6.8 (4.2–10.8)0.03
Total n-6, μg/mL305.5 (187.1–331.1)361.7 (331.6–387.3)426.6 (389.4–573.7)
 % Basic7.1 (4.9–10.4)9.4 (6.4–13.7)5.4 (3.7–7.8)0.07
 % Multivariable8.8 (5.4–14.6)9.7 (5.6–16.8)5.6 (3.4–9.3)0.08
LA, μg/mL194.3 (122.8–212.7)240.3 (214.1–264.2)290.2 (267.2–413.4)
 % Basic7.2 (4.9–10.6)9.6 (6.4–14.3)5.6 (3.9–8.0)0.09
 % Multivariable8.8 (5.3–14.6)9.5 (5.4–16.6)6.2 (3.8–10.2)0.22
AA, μg/mL98.3 (54.8–114.7)124.4 (115.3–132.2)148.1 (134.1–181.8)
 % Basic7.6 (5.2–11.1)8.2 (5.2–12.1)5.8 (4.0–8.5)0.32
 % Multivariable9.0 (5.4–15.0)8.8 (5.3–14.7)5.9 (3.6–9.7)0.16
Ratio n-3/n-60.10 (0.08–0.13)0.14 (0.13–0.15)0.18 (0.15–0.38)
 % Basic7.8 (5.2–12.1)7.7 (5.2–11.4)6.4 (4.5–9.0)0.64
 % Multivariable9.6 (5.4–16.9)7.8 (4.7–12.9)6.8 (4.1–11.1)0.41

Abbreviations: AA, arachidonic acid; ALA, alpha-linolenic acid; LA, linoleic acid.

  • aFrom ANOVA for unbalanced design, type III sum of squares.

  • bMedian (minimum–maximum), all such values.

  • cProportion of p53-positive cells (mean and 95% CI) adjusted for age and sex.

  • dProportion of p53-positive cells (mean and 95% CI) adjusted for age, sex, skin color, propensity to sunburn, β-carotene allocation during the trial, and use of sunscreen on the hands.