Table 3.

Menopausal symptoms and risk of breast cancer by histologic type

Controls (n = 449)Ductal cases (n = 494)Lobular cases (n = 307)Ductal-lobular cases (n = 187)
n (%)n (%)ORc (95% CI)n (%)ORc (95% CI)n (%)ORc (95% CI)
Never had menopausal symptoms51 (11.4)96 (19.4)1.0 (ref)56 (18.2)1.0 (ref)25 (13.4)1.0 (ref)
Ever had menopausal symptoms398 (88.6)398 (80.6)0.5 (0.3–0.7)b251 (81.8)0.5 (0.3–0.8)162 (86.6)0.7 (0.4–1.2)
Number of menopausal symptoms experienced
 159 (13.1)72 (14.6)0.6 (0.4–1.0)52 (16.9)0.7 (0.4–1.3)32 (17.1)1.1 (0.5–2.2)
 2114 (25.4)119 (24.1)0.5 (0.3–0.7)b69 (22.5)0.4 (0.3–0.7)b49 (26.2)0.7 (0.4–1.3)
 ≥3225 (50.1)207 (41.9)0.4 (0.3–0.7)b130 (42.4)0.4 (0.3–0.7)b81 (43.3)0.6 (0.3–1.0)
P for trend0.1260.0490.028
Ever had severe menopausala symptoms180 (100)166 (100)0.5 (0.3–0.7)b115 (100)0.5 (0.3–0.8)b71 (100)0.8 (0.4–1.5)
Number of severe menopausal symptoms among women who ever experienced a menopausal symptom
 Never had menopausal symptoms51961.0 (ref)561.0 (ref)251.0 (ref)
 183 (46.1)81 (48.8)0.5 (0.3–0.8)b52 (45.2)0.5 (0.3–0.9)b42 (59.1)0.9 (0.5–1.7)
 255 (30.6)48 (28.9)0.4 (0.2–0.7)b30 (26.1)0.4 (0.2–0.8)b19 (26.8)0.6 (0.3–1.3)
 ≥342 (23.3)37 (22.3)0.4 (0.2–0.8)b33 (28.7)0.6 (0.3–1.1)10 (14.1)0.4 (0.2–0.9)b
P for trend0.2960.8770.070
Ever had vasomotor symptoms355 (89.2)355 (89.2)0.5 (0.3–0.7)b225 (89.6)0.5 (0.3–0.8)b141 (87.0)0.7 (0.4–1.2)
Ever had urogenital atrophy symptoms257 (64.6)244 (61.3)0.4 (0.3–0.7)b148 (59.0)0.5 (0.3–0.7)b100 (61.7)0.7 (0.4–1.2)
Ever had emotional changes or insomnia170 (42.7)175 (44.0)0.5 (0.3–0.8)b108 (43.0)0.5 (0.3–0.8)b71 (43.8)0.8 (0.4–1.4)
  • aThirty women (13 controls, 12 IDC cases, and 5 ILC cases) had missing data on intensity of menopausal symptoms and excluded from the analysis.

  • bP < 0.05.

  • cAll OR are adjusted for age, year, duration of HT use, and the type of menopause.